THE
INFLUENCE OF PLANTS ON THE MICROBIOME
IN PATIENTS WITH AUTOIMMUNE DISEASES
Gheorghe GIURGIU1, Manole
COJOCARU2,3, Georgeta SINIȚCHI4
1 Deniplant-Aide Sante Medical Center,
Biomedicine, Bucharest, România
deniplant@gmail.com
https://orcid.org/0000-0002-5449-2712
2 Titu Maiorescu University, Faculty of
Medicine, Bucharest, România
3 Academy of Romanian Scientists
cojocaru.manole@gmail.com
https://orcid.org/0000-0002-7192-7490
4 Atopy Allergological Medical Center,
Iași, România
Abstract. Background It is now evident that
the gut microbiota has a profound effect on the host immune system. The interactions between the gut microbiota and host immunity are
complex, dynamic and context-dependent. The gut microbiota and its metabolites
have been shown to influence immune homeostasis both locally and systemically.
Bacterial contents such as lipopolysaccharide and bacterial antigens can induce
a systemic inflammatory environment. The biggest question in the field is
whether inflammation causes gut dysbiosis or dysbiosis leads to disease
induction or propagation.
Objectives To demonstrate role of plants in the
management of disfunctional immune responses. The direct modulation of gut microbiome that could diminish chronic
inflammatory responses and ameliorate adaptive immune responses is major
pathway to stabilize autoimmune diseases.
Materials and methods Recent reports
indicate that dysbiosis is increased in autoimmune diseases. Plant modulation
of the immune system can also have a role in the autoimmune disease, acting to
reduce or delay the onset of immune-mediated diseases. Ongoing research in this
field will ultimately lead to a better understanding of the role of diet and
plants in chronic inflammation in patients with autoimmune diseases.
Results Plants may restore the composition of the gut microbiome and introduce
beneficial functions to gut microbial communities, resulting in amelioration or
prevention chronic inflammatory responses.
Conclusion The gut microbiota is considered to be a
master regulator of immune homeostasis. Besides modifying the gut microbiota,
plants modulate the immune system in patients with autoimmune diseases.
Keywords: plants, autoimmune
diseases, microbiome, immunomodulation
DOI 10.56082/annalsarscibio.2024.2.84
